Quantitative flow cytometric evaluation of CD200, CD123, CD43 and CD52 as a tool for the differential diagnosis of mature B-cell neoplasms
نویسندگان
چکیده
منابع مشابه
Quantitative flow cytometric evaluation of CD200, CD123, CD43 and CD52 as a tool for the differential diagnosis of mature B-cell neoplasms
BACKGROUND Distinction between mature B-cell neoplasms can be difficult due to overlapping of immunologic features and clinical manifestations. This study investigated whether quantifying mean fluorescence intensity of four monoclonal antibodies in a flow cytometry panel is useful for the differential diagnosis and characterization of these disorders. METHODS The expressions of CD52, CD200, C...
متن کاملScientific comment on: “Quantitative flow cytometric evaluation of CD200, CD123, CD43 and CD52 as a tool for the differential diagnosis of mature B-cell neoplasms”☆
cell or directly of the antibody binding capacity using standard 2 ince the 1980s, multiparametric flow cytometry (FCM) was rought to the clinical laboratory for diagnostic immunopheotyping. The expression of antibodies bound to the embrane or intracellular receptors has been generally efined as positive or negative with a cutoff set relative to a onstaining control population. It is known that...
متن کاملFlow cytometric evaluation of B-cell lymphoid neoplasms.
Evaluation of B-lymphocytes is one of the most well-established clinical applications of flow cytometric immunophenotyping. This article addresses general principles of the flow cytometric evaluation of B-cell lymphoid neoplasms, followed by discussion of how flow cytometric data can assist in determining a list of diagnostic possibilities and directing additional testing.
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چکیده ندارد.
Differential expression of CD200 in B-cell neoplasms by flow cytometry can assist in diagnosis, subclassification, and bone marrow staging.
OBJECTIVES To analyze CD200 expression by flow cytometry in a large series of B-cell neoplasms in a variety of tissue types in comparison with benign B-lineage cells. METHODS We measured CD200 expression levels in 505 peripheral blood (PB), bone marrow (BM), and lymphoid tissue biopsy specimens, including 364 cases positive for B-cell leukemias and lymphomas. RESULTS CD200 expression in chr...
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ژورنال
عنوان ژورنال: Revista Brasileira de Hematologia e Hemoterapia
سال: 2017
ISSN: 1516-8484
DOI: 10.1016/j.bjhh.2017.05.002